More than 50 years after the publication of the Harvard Committee Report that sought to define death according to whole-brain function criteria, this document continues to generate a diversity of o...

Zuidema et al. illustrate how empirical AGL studies can benefit from computational models and techniques. Computational models can help clarifying theories, and thus in delineating research questions, but also in facilitating experimental design, stimulus generation, and data analysis. The authors show, with a series of examples, how computational modeling can be integrated with empirical AGL approaches, and how model selection techniques can indicate the most likely model to explain experimental outcomes.

Dans cet article je présente des réflexions sur l�amour-propre, un élément important de l�anthropologie philosophique de Jean-Jacques Rousseau. À la suite de cet exposé, j�examine brièvement des anticipations de ces idées de Rousseau dans les écrits de deux philosophes du siècle précédent, Blaise Pascal et Pierre Nicole.

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

In Democracy and the Claims of Nature, the leading thinkers in the fields of environmental, political, and social theory come together to discuss the tensions and sympathies of democratic ideals and environmental values. The prominent contributors reflect upon where we stand in our understanding of the relationship between democracy and the claims of nature. Democracy and the Claims of Nature bridges the gap between the often competing ideals of the two fields, leading to a greater understanding of each for the (...) other. (shrink)

The book includes contributions by Sarah-Jayne Blakemore, George F. R. Ellis, Christopher D. Frith, Mark Hallett, David Hodgson, Owen D. Jones, Alicia Juarrero, J. A. Scott Kelso, Christof Koch, Hans Küng, Hakwan C. Lau, Dean Mobbs,...

The Morality of Happiness By Julia Annas, Oxford University Press, 1993. Pp. x + 502. ISBN 0–19–507999‐X. £45.00 (hbk), £13.99 (pbk).Dimensions of Creativity By Margaret A. Boden (ed.) MIT Press, 1994. Pp. 242. ISBN 0–262–02368–7. £24.95.Thomas Hobbes and the Science of Moral Virtue By David Boonin‐Vail, Cambridge University Press, 1994. Pp. 219. ISBN 0–521–46209–6. £37.50.Reason and Rhetoric in the Philosophy of Hobbes By Quentin Skinner, Cambridge University Press, 1996. Pp. 477. ISBN 0–521–55436–5. £35.00.Being and the Between By William Desmond, State (...) University of New York Press, 1995. Pp. 557. ISBN 0–7914–2271–2. $19.95.Perplexity and Ultimacy By William Desmond, State University of New York Press, 1995. Pp. 263. ISBN 0–7914–2387–5. $19.95.Evidence and Inquiry: Towards Reconstruction in Epistemology By Susan Haack, Blackwell Publishers, 1994. Pp. x + 259. ISBN 0–631–19679‐X/£14.99 (pbk).Kant's Intuitionalism: A Commentary on the Transcendental Aesthetic By Lorne Falkenstein, University of Toronto Press, 1996. Pp. xvii + 465. ISBN 0–8020–2973–6. $70.00.The Metaphysics of Free Will By John Martin Fischer, Blackwell, 1995. Pp. ix + 273. ISBN 1–55786–8573. £14.99.Identification Papers By Diana Fuss, Routledge, 1995. Pp. 179. ISBN 0–415–90886–8. $16.95.Rorty and Pragmatism: The Philosopher Responds to his Critics Edited by Herman J. Saatkamp, Jr., Vanderbilt University Press, 1995. ISBN 0–8265–1263–1 $24.95.Nietzsche's French Legacy: a Genealogy of Poststructuralism By Alan D. Schrift, Routledge, 1995. Pp. xviii + 198. ISBN 0–415–91146‐X. £40.00.Causal Cognition ‐ A Multidisciplinary Debate Edited by Dan Sperber, David Premack, and Ann James Premack, Clarendon Press, 1995. Pp. 670. ISBN 0–19–852314–9. £00.00. (shrink)

The purpose of this article is to provide a case against certain claims made by modal skeptics with a specific application to the debate about whether conceivability is the right notion to employ in justifying the move from some state of affairs being conceivable to its being metaphysically possible. Does conceivability provide adequate, defeasible grounds for inferring metaphysical possibility? If not, is there a better approach that employs a replacement for conceivability? I argue that conceivability should be abandoned in favor (...) of rational intuitions understood in a way I hope to make clear and precise. To accomplish this purpose, I begin by examing the general way conceivability has been related to metaphysical possibility and opt for a replacement for conceivability. Next, I make clear and precise what I mean by that replacement—rational intuitions. Third, I present three representative accounts of modal knowledge offered by Timothy O’Connor, George Bealer, and Edmund Husserl. O’Connor’s account is externalist, Bealer’s is a hybrid between an internalist and externalist view, and Husserl’s is a purely internalist perspective. While all three are plausible perspectives, I will criticize and reject the first two accounts and argue that Husserl’s way out of modal skepticism is successful. I conclude that Husserl’s employment of rational intuition made precise by his notions of eidetic and categorial intuition, provides a rigorous, fruitful way to ground modal knowledge in general, and de re and de dicto possibility in particular. (shrink)

I distinguish restrictive and permissive multiverse solutions to the problems of evil and no best world. Restrictive multiverses do not admit a single instance of gratuitous evil and they are not improvable. I show that restrictive multiverses unacceptably entail that all modal distinctions collapse. I consider Timothy O’Connor’s permissive multiverse. I show that a perfect creator minimizes aggregative suffering in permissive multiverses only if the actual universe is not included in any actualizable multiverse. I conclude that permissive multiverses do (...) not offer a credible solution to the problems of evil and no best world. (shrink)

This chapter contains sections titled: Section One: The Backdrop for Locating Consciousness in a Naturalist Ontology Section Two: The AC Section Three: John Searle and Contingent Correlation Section Four: Timothy O'Connor and Emergent Necessitation Section Five: Colin McGinn and Mysterian “Naturalism” Conclusion Further Reading References.

The Body in Sound, Music and Performance brings together cutting-edge contributions from women working on and researching contemporary sound practice. This highly interdisciplinary book features a host of international contributors and places emphasis on developments beyond the western world, including movements growing across Latin America. Within the book, the body is situated as both the site and centre for knowledge making and creative production. Chapters explore how insightful theoretical analysis, new methods, innovative practises, and sometimes within the socio-cultural conditions of (...) racism, sexism and classicism, the body can rise above, reshape and deconstruct understood ideas about performance practices, composition, and listening/sensing. This book will be of interest to both practitioners and researchers in the fields of sonic arts, sound design, music, acoustics and performance. (shrink)

What does it mean to ‘drop out’ of therapy? Many definitions of ‘dropout’ have been proposed, but the most widely accepted is the client ending treatment without agreement of their therapist. However, this is in some ways an external criterion that does not take into account the client’s experience of therapy, or reasons for ending it prematurely. This study aimed to identify whether there were more meaningful categories of dropout than the existing dropout definition, and to test whether this refined (...) categorisation of dropout was associated with clinical outcomes. This mixed-methods study used a subset of data from the IMPACT trial, which investigated psychological therapies for adolescent depression. Adolescents were randomly allocated to a treatment arm (Brief Psychosocial Intervention; Cognitive-Behavioural Therapy; Short-Term Psychoanalytic Psychotherapy). The sample for this study comprised 99 adolescents, aged 11-17 years. 32 were classified as having dropped out of treatment and participated in post-therapy qualitative interviews about their experiences of therapy. For 26 dropout cases, the therapist was also interviewed. 67 cases classified as having completed treatment were included to compare their outcomes to dropout cases. Interview data for dropout cases were analysed using ideal type analysis. Three types of dropout were constructed: ‘dissatisfied’ dropout, ‘got-what-they-needed’ dropout, and ‘troubled’ dropout. ‘Dissatisfied’ dropouts reported stopping therapy because they did not find it helpful. ‘Got-what-they-needed’ dropouts reported stopping therapy because they felt they had benefitted from therapy. ‘Troubled’ dropouts reported stopping therapy because of a lack of stability in their lives. The findings indicate the importance of including the perspective of clients in definitions of drop out, as otherwise there is a risk that the heterogeneity of 'dropout' cases may mask more meaningful distinctions. Clinicians should be aware of the range of issues experienced by adolescents in treatment that lead to disengagement. Our typology of dropout may provide a framework for clinical decision-making in managing different types of disengagement from treatment. (shrink)

Introduction , Sophie Gibb 1. Mental Causation , John Heil 2. Physical Realization without Preemption , Sydney Shoemaker 3. Mental Causation in the Physical World , Peter Menzies 4. Mental Causation: Ontology and Patterns of Variation , Paul Noordhof 5. Causation is Macroscopic but not Irreducible , David Papineau 6. Substance Causation, Powers, and Human Agency , E. J. Lowe 7. Agent Causation in a Neo-Aristotelian Metaphysics , Jonathan D. Jacobs and Timothy O’Connor 8. Mental Causation and Double Prevention (...) , Sophie Gibb 9. The Identity Theory as a Solution to the Exclusion Problem , David Robb 10. Continuant Causation, Fundamentality, and Freedom , Peter Simons 11. There is no Exclusion Problem , Steinvor Tholl Arnadottir and Tim Crane. (shrink)

This paper analyses Australian policy makers’ use of quantification and technologies of government to implement the project of Australian wheat export market liberalisation. I draw upon policy documents to analyse how quantification has been used to construct a simplified, governable conception of the wheat industry. Policy makers, I suggest, acted upon this constructed reality through assemblages of technologies such as performance objectives, audit, cost-benefit analysis and econometric modelling to facilitate wheat export market deregulation. In addition, this paper shows how quantification (...) was used to delegitimise the social consequences of deregulation and marginalise farmers’ opposition to this shift. Thus, the erasure of the social world enabled policy makers to construct economic objectives such as efficiency and productivity as serving the national interest. (shrink)

A puzzle has been presented in the recent past in Northern Ireland: what is the correct description of the person who dies as a result of a hungerstrike? For many the simple answer is that such a person commits suicide, in that his is surely a case of . Where then is the puzzle? It is that a number of people do not see such deaths as suicides. I am not here referring to political propagandists or paramilitaries, for whom the (...) correct description of such deaths is or (to quote advertisements in the Belfast nationalist press at the time of Bobby Sands' death). I am rather thinking of some theologians who, despite being opposed to the hunger-strike and indeed publicly condemning the whole campaign, refused to describe what the hunger-strikers did as suicide. (shrink)

Do you ever feel flawed, anxious, or afraid--like something might be wrong, but you're not sure what? The truth is, we all feel that way sometimes (or even most of the time!). We're trapped by a limited sense of self, held back by our own anxieties, fears, and compulsions. Mindfulness can offer intermittent relief from these contrived narratives, showing us how to be present, open, and available in the moment by observing our thoughts and feelings. This is all wonderful--until the (...) fears and doubts rush back in. How to Be a Spiritual Rebel offers more than simple mindfulness. Drawing on spiritual practices and recent findings in neuroscience, this groundbreaking guide will help you examine the psychological barriers that block your spiritual growth and keep you from embracing true liberation. You'll learn to cultivate courage, view your thoughts and feelings without letting them define you, and find guidance and support as you navigate the route to boundless freedom without fear or self-limiting attachments.If you're ready to take mindfulness--and spirituality--to the next level and experience true freedom and fulfillment, this candid, entertaining, and jargon-free guide will help point the way.--amazon.com. (shrink)

The trauma associated with resettling in a new country is considerable for young people who have experienced (forced) migration. The loss of place and loss of connection with family and friends is significant. Resettlement in unfamiliar, suburban and rural places can accentuate this sense of loss. In Australia, the difficulty of this challenge is amplified by nationalistic discourses of Australian identity and citizenship, which construct and preserve a particularly British notion of ‘Australian-ness’. This article explores the relationship between place and (...) displacement and problematises the development and use of nationalistic identities as a spatial management method for creating social division and exacerbating the impacts of displacement, particularly for young people resettling in a new environment following (forced) migration. Building on this we suggest that theorisations of space, place and belonging offer new opportunities for social work education to enhance students’ understanding of displacement and social work practice, particularly in relation to young peoples’ experiences of (forced) migration. (shrink)

The article begins from a previous attempt by Glenn Graber "(Journal of Religious Ethics 1973)" to characterize Tillich's metaethics as an ontologically based self-realization theory. After proposing a modification of Graber's thesis, the article attempts to show that some of the ambiguities noted by Graber in Tillich's position-notably the tension between a formal and a material account of ethics-have their roots in his early German writings. There the treatment of ethics as a "cultural science" led Tillich to posit a formal, (...) philosophical moment (Kant), a cultural-historical moment, and a normative moment. He refused to identify the latter with theological ethics and instead, following his reformulation of the concept of religion, found it in theonomous forms of legal and community structures, identified with socialism. When Tillich abandoned the "cultural sciences" approach and ceased to see socialism as the concrete and normative content of ethics, he was forced to replace it with a notion of essential human nature and "new being," coexisting uneasily with Kantian formalism. (shrink)

Disorders of volition are often accompanied by, and may even be caused by, disruptions in the phenomenology of agency. Yet the phenomenology of agency is at present little explored. In this paper we attempt to describe the experience of normal agency, in order to uncover its representational content.

In this paper I critically examine the implications of the uncodifiability thesis for principlism as a pluralistic and non-absolute generalist ethical theory. In this regard, I begin with a brief overview of W.D. Ross’s ethical theory and his focus on general but defeasible prima facie principles before turning to 2) the revival of principlism in contemporary bioethics through the influential work of Tom Beauchamp and James Childress; 3) the widespread adoption of specification as a response to the indeterminacy of abstract (...) general principles and the limitations of balancing and deductive approaches; 4) the challenges raised to fully specified principlism by the uncodifiability thesis and 5) finally offer a defense of the uncodifiability thesis against various critiques that have been raised. (shrink)

This paper explores how emotions are expressed in the endangered Gunwinyguan language Kunbarlang and compares these expressions to those in the neighbouring Gunwinyguan language Bininj Kunwok, and neighbouring languages from other language families, Mawng (Iwaidjan) and Ndjébbana (Maningridan). As well as considering body-based emotion expressions and the tropes (metaphors and metonymies) they instantiate, we consider the range of other (non-body-based) expressions and tropes available in each language. These provide an important point of comparison with the body-part expressions, which are limited (...) to expressions based on noun incorporation in the Gunwinyguan languages and, correspondingly, a more limited range of tropes. By outlining and comparing the linguistic tropes used to express emotions in these four languages in the highly multilingual yet socioculturally unified context of western Arnhem Land, we aim to shed further light on the relationships between linguistic figurative features and conceptual representations of emotions. (shrink)

Journal of Philosophy of Education, EarlyView.

Secondary education around the world has been significantly disrupted by covid-19. Students have been forced into new ways of independent learning, often using remote technologies, but without the social nuances and direct teacher interactions of a normal classroom environment. Using data from the School Attitudes Survey—which surveys students regarding the perceived level of difficulty, anxiety level, self-efficacy, enjoyability, subject relevance, and opportunities for creativity with regards to each of their school subjects—this study examines students' responses to this disruption from two (...) very different schools with two very different experiences of the pandemic. This paper reports on the composite attitudinal profiles of students in the senior secondary levels at each school. The findings challenged our expectation that the increased difficulty and anxiety caused by the disruption would reduce perceived opportunities for creativity. Indeed, our analyses showed that the students at both schools demonstrated generally positive attitudes toward their learning and strongly associated opportunities for creativity with other attitudinal constructs including enjoyability, subject relevance, and self-efficacy. These complex associations made by the students appear to have buffered the impacts of the disruption, and they may even have supported creative resilience. (shrink)